Pfizer Halts Melanoma Trial: tremelimumab

4-2-2008 —

Pfizer said on Tuesday it was halting a late stage study of its experimental drug for advanced melanoma after data showed it was no better than standard chemotherapy.

Pfizer said researchers will work with their patients to determine if they are benefiting from treatment with the drug, tremelimumab, and should therefore continue treatment.

But its review of interim data from the phase 3 trial found that it ultimately would not demonstrate superiority to standard chemotherapy, leading to the decision to discontinue the study. Phase 3 is typically the final stage of human testing before a drug is submitted for an approval decision.

"Although this outcome is disappointing, Pfizer remains committed to investigating new treatment options for patients with melanoma, a high risk area of research with significant unmet medical need," Charles Baum, who heads Pfizer's oncology therapeutic area, said in a statement.

The company said full data from the phase 3 study was being analyzed and would likely be made available at a major cancer meeting in June.

Pfizer said it was not abandoning tremelimumab.