Melanoma is a cancer that starts in melanocytes, the cells that make the pigment responsible for much of the skin's color. Most melanomas begin in the skin, although melanocytes also occur in the eyes and other parts of the body. The American Cancer Society's melanoma overview explains the disease and the different places it can begin.

Melanoma differs from the more common basal cell and squamous cell skin cancers. The National Cancer Institute's skin cancer patient page explains that melanoma is less common but more likely to grow into nearby tissue and spread elsewhere. A general description cannot tell someone what a particular spot is, what a diagnosis means for them, or which treatment belongs in their care.
Noticing change without trying to diagnose it
A changing spot can raise questions that deserve a doctor's attention. The American Academy of Dermatology's melanoma pages describe ways to notice warning signs and explain why finding melanoma early matters. Their information includes checking the skin and nails, recognizing changes, and the close examination a dermatologist may carry out. Here, the self-exam page explains those ideas with words and a warning-sign table.
Looking at skin is a way to notice something worth showing a doctor. It cannot establish that a spot is harmless or confirm that it is melanoma. The same limit applies to a remembered rule or a photograph. This reference offers no photographs of skin disease and does not compare a reader's skin with pictures. Questions about a new or changing area belong with a doctor or dermatologist.
Finding a starting point
A person wondering about a spot may want to begin with skin checks and the basics. A family member reading a diagnosis letter may want explanations of a biopsy, the pathology report, or staging. Someone returning to ordinary routines after treatment may want to understand follow-up care or read about feelings, activity, and the cost of care. The page groups below make these subjects easier to find without treating them as a sequence everyone must follow.
Each topic has a different purpose. A definition explains a word. A page about a test explains what an agency says that test is used for. A stage page describes a classification and the categories of treatment agencies discuss. A research summary explains what a study examined and reported. None of these can substitute for the details of a person's own medical record or a conversation with the team providing care.
The MedlinePlus melanoma topic brings together information on diagnosis, prevention, treatment, living with melanoma, and research. Its organization reflects how many different questions can sit under the same disease name. This reference takes a similarly broad view of the subjects a reader may need, while keeping individual pages focused on a clear topic.
Reading at a comfortable pace
Technical words are explained where they first appear and can be followed to the glossary. The glossary is also useful when a word occurs in a letter but the surrounding sentence is hard to follow. Definitions describe general meanings; they do not interpret a finding in a person's report. A care team can explain how that finding fits with the rest of the information they have.
Longer pages have a contents list. Many start with key points and some close with questions that a reader might bring to their own care team. These questions are examples of topics for discussion, rather than requests for a particular test or treatment. It is fine to read only the section that answers an immediate question and return to another subject later.
There are also pages for readers who want to understand sun safety without having a diagnosis. They explain ultraviolet light, the UV Index, sunscreen labels, clothing labels, and shade as public health agencies describe them. The skin-science page offers a general introduction to the skin's layers, pigment cells, supporting tissue, and ordinary repair processes. It is written for any curious reader.
Sources and limits
Melanoma International is an independent, plain-language reference for patients and families. Its pages draw on public health agencies, cancer and dermatology societies, and published research. Citations appear beside the information they support, with the source named so that readers can follow the fuller explanation. The annotated reading guide describes what each source covers before a reader leaves this reference.
Public information applies to topics and groups of people. An individual question can involve findings, circumstances, and preferences that are absent from a general page. Your own doctor or care team is the right source for questions about your skin, diagnosis, or treatment. The About page explains the reference's independence and its limits in more detail.
Understanding melanoma
- Melanoma: the basics
Start with pigment cells, risk factors, and the difference between melanoma and other skin cancers.
- Types of melanoma: skin subtypes, eye (uveal) and mucosal melanoma
Learn the main skin subtypes and the meanings of eye and mucosal melanoma.
- Checking your skin: the self-exam and the ABCDE warning signs
Read how agencies describe skin checks, changing spots, and the ABCDE warning signs.
- Melanoma glossary: words you may see in reports and letters
Find plain meanings for words used in reports, letters, and discussions.
- How skin works: layers, collagen, repair and what sunlight does over time
Explore skin layers, collagen, pigment, ordinary repair, and changes linked with sunlight.
After a diagnosis
- Newly diagnosed with melanoma: understanding the first weeks
Understand the information and unfamiliar terms that can arrive with a diagnosis.
- Skin biopsy: how a suspicious spot is diagnosed
Learn what a skin sample can show and how it reaches a laboratory.
- Reading a melanoma pathology report
Understand the structure of a report and the findings its terms describe.
- Sentinel lymph node biopsy, explained
Read what a sentinel node is and what this staging procedure examines.
Treatment & trials
- Early-stage melanoma and treatment categories
Understand early stages and the treatment categories agencies describe.
- Stage III melanoma: lymph nodes, surgery and the treatments studied after it
Read about nearby lymph nodes and treatment categories studied after surgery.
- Stage IV melanoma: what metastatic means and how treatment is studied
Understand spread to distant sites and the categories used in treatment research.
- Clinical trials: how they work and how people find them
Learn what a trial involves, how consent works, and how costs are discussed.
- After treatment: follow-up care, skin checks and life beyond melanoma
Read about follow-up visits, medical records, and adjusting after treatment.
Sun safety
- Preventing melanoma: ultraviolet light, sunburn, tanning beds and what the evidence shows
Explore ultraviolet light, tanning, and the limits of prevention evidence.
- Sunscreen and sun-protective clothing: reading the labels
Understand broad spectrum, SPF, water resistance, and clothing labels.
- Safe from the sun: the UV Index, shade and outdoor days
Learn what the UV Index means for shade and outdoor settings.
Care & support
- Finding doctors experienced in melanoma
Understand specialist roles and the questions involved in finding care.
- NCI-designated cancer centers and accredited hospitals: what the labels mean
Read what designation and accreditation describe, without a list of institutions.
- Choosing a hospital for melanoma care: designations, accreditation and experience
Explore experience, teamwork, practical arrangements, and hospital questions.
- Second opinions and shared decisions: taking part in your own care
Read about another clinical opinion, pathology review, and shared discussions.
- Coping with a melanoma diagnosis: feelings, distress and where support comes from
Understand feelings, distress, caregivers, and established sources of support.
- Physical activity during and after cancer treatment: what the guidelines say
Read what cancer-activity guidance and research say, without an exercise plan.
- Health coverage and the cost of melanoma care
Understand coverage, records, trial costs, and financial strain.
Resources
- Resources: where to read more
Find a route through the resource pages and related reference articles.
- Reliable melanoma information online: an annotated guide
Use a grouped guide to public agencies, societies, and other reading sources.
- Melanoma information around the world
Explore melanoma and sun-safety information from organizations outside the United States.
- Articles
Browse reference articles on care, costs, feelings, activity, and skin science.
- About Melanoma International
Read about this independent reference, its sources, and its limits.